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The test was two sided at the 0.05 significance level, and effect size (for the A-dopamine versus oral l-dopa alone treatment) was estimated using Hedges g for paired data and calculated using rank-transformed values 32

It is known that reduction in CD38 expression on BM and circulating MM cells occurs rapidly after daratumumab initiation with significantly lower expression levels after the first infusion compared with baseline (potentially due to elimination of MM cells with high CD38 levels, endocytosis, or release in microvesicles), that may persist for at least 6 months after discontinuation [35]

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